Chemical Formula of Finasteride:
Indication of Finasteride:
Indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to alleviate symptoms, minimize the risk of acute urine retention, and reduce the necessity for surgery such as TURP or prostatectomy.
Male pattern hair loss (androgenetic alopecia, hereditary alopecia, or c) is treated with this medication.
Mechanism of action of Finasteride:
Finasteride inhibits Type II 5-reductase, a nuclear-bound steroid intracellular enzyme found largely in the prostatic stromal cell that transforms the androgen testosterone into the more active metabolite 5-dihydrotestosterone (DHT). DHT is thought to be the main androgen involved in the growth and expansion of the prostate gland. When it accumulates within the prostate gland, it acts as a hormonal mediator for hyperplasia.
Finasteride’s mode of action is based on the development of a stable complex with Type II 5-reductase in vitro and in vivo, which inhibits the enzyme preferentially. Finasteride operates selectively, preferring to target the human Type II 5-reductase over the Type I enzyme by a factor of 100.
The mechanism of action in men with androgenic alopecia has not been fully elucidated, however, finasteride has been proven to lower scalp DHT levels to those found in the hairy scalp, lower serum DHT, promote hair regrowth, and halt hair loss.
How to use Finasteride:
Finasteride can be taken with or without a meal. It doesn’t matter when you take it; just make sure you do it at the same time every day.
With a glass of water, swallow your finasteride tablets whole. They must not be broken or crushed.
History of Finasteride:
Finasteride is a synthetic 4-azasteroid chemical 13 that inhibits steroid Type II 5-reductase, an intracellular enzyme that transforms testosterone to 5-dihydrotestosterone (DHT). It exerts antiandrogenic effects in the same way that dutasteride, another 5-alpha-reductase inhibitor, does.
Both benign prostatic hyperplasia and androgenic alopecia are androgen-dependent illnesses marked by excessive levels of DHT in the prostate gland. Alpha-blockers such as tamsulosin and terazosin are also used to treat benign prostatic hyperplasia. In contrast to alpha-blockers, which try to relieve symptoms quickly, 5-reductase inhibitors aim to treat the underlying condition.
Side effects of Finasteride:
Common side effects are:
- Having trouble getting an erection and a lack of desire to have sex
- issues with ejaculating, such as a lack of or inability to ejaculate
Keep this drug away from heat, moisture, and light at 68°F to 77°F (20°C to 25°C). Keep any medications out of children’s reach. After the expiration date, throw away any unused medicine. Do not dump or spill unused drugs down the sink or drain.