History of Menotropins:
Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) isolated from the urine of postmenopausal women are found in menotropins. It is administered either subcutaneously or intramuscularly as a fertility medicine.
Indication of Menotropins:
Menotropins are a purified combination of human luteinizing hormone and follicle-stimulating hormone that are used to treat infertility in women. Menotropins induce late follicular maturation and resumption of oocyte meiosis, as well as initiating rupture of the pre-ovulatory ovarian follicle, and are used to treat female infertility.
Mechanism of action of Menotropins:
Menotropins, as a combination medication, bind to the follicular stimulating hormone receptor, causing ovulation when the endogenous luteinizing hormone is insufficient. It also attaches to the LH receptor, causing normal hormone release to occur. Because the medication contains both FSH and LH, it stimulates ovarian follicular development and gonadal steroid production in women.
FSH is the principal driver of follicular recruitment and expansion during early folliculogenesis, whereas LH is engaged in the physiological mechanisms that lead to the establishment of a competent pre-ovulatory follicle and is necessary for ovarian steroidogenesis.
How to use Menotropins:
An initial dose of HMG 150IU is given subcutaneously every day starting on cycle day 2 or 3. After 5 days, adjust the dose based on the woman’s ovarian response, which is measured by ultrasound follicular growth and serum estradiol levels.
Additional dosage modifications should not be made more frequently than every 2 days or by more than 150 International Units each time.
Side effects of Menotropins:
Common side effects are:
- Body rashes Gastrointestinal symptoms (nausea, vomiting, diarrhoea, abdominal cramps, bloating)
- Pain, rash, swelling, and/or irritation at the site of injection
- Body rashes
Keep this drug away from heat, moisture, and light at 68°F to 77°F (20°C to 25°C). Keep any medications out of children’s reach. After the expiration date, throw away any unused medicine. Do not dump or spill unused drugs down the sink or drain.